Background：Integrin alpha-5/beta-1 is a receptor for ibrinogen.
Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin.
Integrin alpha-4/beta-1 is a receptor for VCAM1.
It recognizes the sequence Q-I-D-S in VCAM1.
Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.
It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Integrin alpha-V/beta-1 is also a receptor for vitronectin.
Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro).
When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
仕様
サイズ：25ug
Source：Biotinylated Human ITGAV&ITGB1 Heterodimer Protein, His,Avitag&Tag Free (IT1-H82W6) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1) (Accession # NP_002201.1 (ITGAV) & NP_002202.2 (ITGB1)).
Molecule：Integrin alpha V beta 1
Synonyms：Integrin alpha V beta 1,ITGAV&ITGB1
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1)
Characteristics：Biotinylated Human ITGAV&ITGB1 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 114.7 kDa (ITGAV) and 83.7 kDa (ITGB1). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag) and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 135-150 kDa (ITGAV) and 100-115 kDa (ITGB1) respectively due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
