Background：V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family.
VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains.
The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs).
VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity.
VTCN1 involved in promoting epithelial cell transformation.
仕様
サイズ：100ug
Source：Human B7-H4, Fc Tag, low endotoxin (B74-H5256) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # Q7Z7D3-1).
Molecule：B7-H4
Synonyms：B7-H4,VTCN1,B7S1,B7h.5
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Phe 29 - Ala 258
Conjugate：Unconjugated
Accession：NP_078902.2
Molecular Weight：51.8 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 66-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 0.01 EU per ug by the LAL method.
