Background：Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells.
IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases.
Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms.
High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仕様
サイズ：100ug
Source：Mouse IL-17A, His Tag (CT8-M5240) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Ala 158 (Accession # Q62386-1).
Molecule：IL-17A
Synonyms：IL-17A,Interleukin-17A,CTLA-8,IL-17
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ala 26 - Ala 158
Conjugate：Unconjugated
Accession：NP_034682.1
Molecular Weight：15.8 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 17-19 kDa and 21-24 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
