Background：CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3).
CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages.
CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells.
In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
仕様
サイズ：100ug
Source：Human CD58, Fc Tag (LF3-H5256) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Arg 215 (Accession # AAH05930).
Molecule：CD58
Synonyms：CD58,LFA3,Ag3
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Phe 29 - Arg 215
Conjugate：Unconjugated
Accession：AAH05930
Molecular Weight：48.1 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.1 kDa. As a result of different glycosylation, the protein migrates as 60-75 kDa under reducing (R) condition, and 125-150 kDa under non-reducing (NR) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
