86-7925-89 ［取扱停止］Biotinylated Human VEGF165 Protein, His,Avitag 25ug VE5-H82Q0
特徴
- Background：VEGF165 is the most abundant splice variant of VEGF-A.
- VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells.
- VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability.
- VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes.
- VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix.
- VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2.
- VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling.
- Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin.
- VEGF plays a key role in tumor angiogenesis in many cancers.
仕様
- サイズ：25ug
- Source：Biotinylated Human VEGF165, His,Avitag (VE5-H82Q0) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 191 (Accession # P15692-4).
- Molecule：VEGF165
- Synonyms：RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF
- Species：Human
- Tag：His Tag & Avi Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 27 - Arg 191
- Conjugate：Precision Avi
- Molecular Weight：22.4 kDa (monomer)
- Characteristics：This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 22.4 kDa (monomer). As a result of glycosylation, the protein migrates as 25-33 kDa (monomer) under reducing (R) condition, and 42-55 kDa (homodimer) under non-reducing (NR) condition (SDS-PAGE).
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：25ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7925-89
Biotinylated Human VEGF165 Protein, His,Avitag 25ug
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86-7925-90
Biotinylated Human VEGF165 Protein, His,Avitag 200ug
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