Background：Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs).
CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages.
This receptor mediates most, if not all, of the biological effects of this cytokine.
Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation .
Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.
Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries.
The increased receptor expression causes microglia to become more active.
Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
仕様
サイズ：100ug
Source：Cynomolgus M-CSF R, Fc Tag (CSR-C5252) is expressed from human 293 cells (HEK293). It contains AA Ile 99 - Pro 596 (Accession # G7P8P1).
Molecule：M-CSF R
Synonyms：CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Species：Cynomolgus
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ile 99 - Pro 596
Conjugate：Unconjugated
Molecular Weight：81.9 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 81.9 kDa. As a result of glycosylation, the protein migrates as 110-125 kDa under reducing (R) condition, and 200- 240 kDa under non-reducing (NR) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
