86-7925-50　［取扱停止］Human Transferrin Protein, His Tag (MALS verified) 200ug　TRN-H4229

特徴

• Background：Transferrin is also known as Serotransferrin, Beta-1 metal-binding globulin, TF, and is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids.
• Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h).
• The affinity of transferrin for Fe(III) is extremely high (1023 M−1 at pH 7.4) but decreases progressively with decreasing pH below neutrality.When not bound to iron, it is known as "apo-transferrin”.
• In humans, transferrin consists of a polypeptide chain containing 679 amino acids.
• It is a complex composed of alpha helices and beta sheets to form two domains (the first situated in the N-terminus and the second in the C-terminus).
• The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site.
• The liver is the main source of manufacturing transferrin, but other sources such as the brain also produce this molecule .
• Transferrin is also associated with the innate immune system.
• Transferrin is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacteria survival in a process called iron withholding.
• The level of transferrin decreases in inflammation.
• The metal binding properties of transferrin have a great influence on the biochemistry of plutonium in humans.
• Transferrin has a bacteriocidal effect on bacteria, in that it makes Fe3+ unavailable to the bacteria.Carbohydrate deficient transferrin increases in the blood with heavy ethanol consumption and can be monitored via laboratory testing.