Background：Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family.
HCF2 is expressed predominantly in liver.
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate.
In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III).
In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
仕様
サイズ：50ug
Source：Human Serpin D1, His Tag (HC2-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ser 499 (Accession # AAH35028).
Molecule：Serpin D1
Synonyms：SerpinD1,HCF2,HLS2,HC-II
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gly 20 - Ser 499
Conjugate：Unconjugated
Accession：AAH35028
Molecular Weight：55.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.7 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
