Background：P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM).
SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets.
In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies.
In unactivated platelets SELP is stored in α-granules.
The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan.
Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.
仕様
サイズ：100ug
Source：Human P-Selectin, His Tag (SEP-H52E4) is expressed from human 293 cells (HEK293). It contains AA Trp 42 - Ala 771 (Accession # AAN06828).
Molecule：P-Selectin
Synonyms：P-Selectin,CD62P,SELP,GMP-140
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Trp 42 - Ala 771
Conjugate：Unconjugated
Accession：AAN06828
Molecular Weight：81.8 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 81.8 kDa. The protein migrates as 110-125 kD under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
