86-7925-22　［取扱停止］Human PDGF R beta / CD140b Protein, Fc Tag 1mg　PDB-H5252

特徴

• Background：Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called J03278, M21616, CD140B, JTK12, PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB and has a tyrosine-protein kinase activity.
• Is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family.
• The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D).
• The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs).
• Other class III RTKs are CSF1R, KIT and FLT3.
• PDGF binding induces receptor homo- and heterodimerization and signal transduction.
• The expression of the α and β receptors is independently regulated in various cell types.
• Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist.
• The ligands form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD).
• The four PDGFs are inactive in their monomeric forms.
• The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β.
• These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ.
• PDGF-CC specifically interacts with PDGFR-αα and -αβ, but not with –ββ, and thereby resembles PDGF-AB.
• PDGF-DD binds to PDGFR-ββ with high affinity, and to PDGFR-αβ to a much lower extent and is regarded as PDGFR-ββ specific.
• PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.