Background：Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG).
TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11.
TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro.
Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B.
TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
仕様
サイズ：100ug
Source：Human Osteoprotegerin, His Tag (TNB-H5220) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Leu 401 (Accession # NP_002537).
Molecule：Osteoprotegerin
Synonyms：TNFRSF11B,OCIF,OPG,Osteoprotegerin
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Glu 22 - Leu 401
Conjugate：Unconjugated
Accession：NP_002537
Molecular Weight：44.4 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.4 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
