86-7925-05　［取扱停止］Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin 200ug　CSR-H5258

特徴

• Background：Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs).
• CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages.
• This receptor mediates most, if not all, of the biological effects of this cytokine.
• Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation .
• Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.
• Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries.
• The increased receptor expression causes microglia to become more active.
• Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.