86-7924-92 ［取扱停止］Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free 100ug IT6-H52E1
特徴
Background：Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V.
Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin.
It recognizes the sequence R-G-D in its ligands.
Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1.
Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes.
This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
仕様
サイズ：100ug
Source：Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-H52E1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gly 22 - Asn 707 (ITGB6) (Accession # NP_002201.1 (ITGAV) & AAI21179.1 (ITGB6)).
Molecule：Integrin alpha V beta 6
Synonyms：Integrin alpha V beta 6,ITGAV&ITGB6
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Phe 31 - Val 992 (ITGAV) & Gly 22 - Asn 707 (ITGB6)
Conjugate：Unconjugated
Accession：NP_002201.1 (ITGAV) & AAI21179.1 (ITGB6)
Molecular Weight：112.9 kDa (ITGAV) & 79.6 kDa (ITGB6)
Characteristics：Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 112.9 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 80-90 kDa (ITGB6) and 130-150 kDa (ITGAV) respectively due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 150 mM NaCl, pH7.5
Package Size：100ug*1
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