Background：Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18.
IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation.
This function requires SMAD3.
Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines.
Furthermore,IL1F7b can also inhibit dendritic cell activation.
仕様
サイズ：50ug
Source：Human IL-37b, His Tag (ILB-H5141) is expressed from E.coli cells. It contains AA Val 46 - Asp 218 (Accession # AAH20637.1).
Molecule：IL-37
Synonyms：IL1F7,IL37,FIL1Z,IL1H4,IL1RP1
Species：Human
Tag：His Tag
Expression Systems：E.coli
Expression Rigeion：Val 46 - Asp 218
Conjugate：Unconjugated
Accession：AAH20637.1
Molecular Weight：20.3 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.3 kDa. The protein migrates as 21-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
