Background：Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family.
Its binding with its receptor induces apoptosis.
Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain.
Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively.
Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system.
Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors.
Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
仕様
サイズ：50ug
Source：Human Fas Ligand, His Tag, active trimer (FAL-H5241) is expressed from human 293 cells (HEK293). It contains AA Pro 134 - Leu 281 (Accession # AAH17502.1).
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.8 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
