86-7923-67 ［取扱停止］Human Dkk-3 (R335G) Protein, His Tag 20ug DK3-H5220
特徴
- Background：Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region.
- And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels.
- DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors.
- Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors.
- Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1.
- DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
仕様
- サイズ：20ug
- Source：Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).
- Molecule：Dkk-3
- Synonyms：DKK3,REIC,RIG
- Species：Human
- Tag：His Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 22 - Ile 350
- Conjugate：Unconjugated
- Accession：NP_001018067.1 (R335G)
- Molecular Weight：37.0 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.0 kDa. The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：20ug*1
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
86-7923-67
Human Dkk-3 (R335G) Protein, His Tag 20ug
|
|
|
86-7923-68
Human Dkk-3 (R335G) Protein, His Tag 200ug
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|