Background：Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily.
TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats.
Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.
TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding.
The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
仕様
サイズ：50ug
Source：Human DcR3, Fc Tag (TNB-H5255) is expressed from human 293 cells (HEK293). It contains AA Val 30 - His 300 (Accession # O95407-1).
Molecule：DcR3
Synonyms：TNFRSF6B,DCR3,TR6,M68
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Val 30 - His 300
Conjugate：Unconjugated
Accession：AAH17065
Molecular Weight：56.2 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
