86-7923-16 ［取扱停止］Human BACE-1 Protein, Fc Tag 200ug BA1-H5261
特徴
- Background：Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
- BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells.
- The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.
- This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP).
- Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP.
- Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99.
- The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.
仕様
- サイズ：200ug
- Source：Human BACE-1, Fc Tag (BA1-H5261) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Thr 457 (Accession # NP_036236.1).
- Molecule：BACE-1
- Synonyms：BACE1,ASP2,BACE,FLJ90568,HSPC104,KIAA1149,Memapsin-2
- Species：Human
- Tag：Fc Tag
- Expression Systems：HEK293
- Expression Rigeion：Thr 22 - Thr 457
- Conjugate：Unconjugated
- Accession：NP_036236.1
- Molecular Weight：75.2 kDa & 72.6 kDa
- Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The Human BACE-1 will be further processed into mature form (Glu 46-Thr 457). The protein has a calculated MW of 75.2 kDa (pro-form) and 72.6 kDa (mature-form). The protein migrates as 80-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：50 mM Tris, 100 mM Glycine, pH7.5
- Package Size：200ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7923-15
Human BACE-1 Protein, Fc Tag 1mg
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86-7923-16
Human BACE-1 Protein, Fc Tag 200ug
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