Background：Annexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium.
PS is predominantly located in membrane leaflets, which face the cytosol.
However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface.
This machinery is activated during the execution of apoptosis.
Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities.
Annexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell.
Annexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation.
The presence of antibodies to Annexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).
仕様
サイズ：100ug
Source：Human ANXA5, Tag Free (AN5-H5118) is expressed from E.coli cells. It contains AA Met 1 - Asp 320 (Accession # P08758-1).
Molecule：Annexin A5
Synonyms：ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5
Species：Human
Tag：Tag Free
Expression Systems：E.coli
Expression Rigeion：Met 1 - Asp 320
Conjugate：Unconjugated
Accession：AAH01429
Molecular Weight：35.9 kDa
Characteristics：This protein carries no "tag". The protein has a calculated MW of 35.9 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
