86-7922-99 ［取扱停止］Human Annexin A5 Protein, His Tag 100ug AN5-H5123
特徴
- Background：Annexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium.
- PS is predominantly located in membrane leaflets, which face the cytosol.
- However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface.
- This machinery is activated during the execution of apoptosis.
- Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities.
- Annexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell.
- Annexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation.
- The presence of antibodies to Annexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).
仕様
- サイズ：100ug
- Source：Human Annexin A5, His Tag (AN5-H5123) is expressed from E.coli cells. It contains AA Met 1 - Asp 320 (Accession # P08758-1).
- Molecule：Annexin A5
- Synonyms：ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5
- Species：Human
- Tag：His Tag
- Expression Systems：E.coli
- Expression Rigeion：Met 1 - Asp 320
- Conjugate：Unconjugated
- Accession：AAH01429
- Molecular Weight：36.8 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.8 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>98% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：100ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7922-98
Human Annexin A5 Protein, His Tag 1mg
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86-7922-99
Human Annexin A5 Protein, His Tag 100ug
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