Background：IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses.
The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells.
Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).
Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis.
A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13.
Interleukin-4 receptor has been shown to interact with SHC1.
仕様
サイズ：50ug
Source：Cynomolgus / Rhesus macaque IL-4 R alpha, Fc Tag (ILR-C5258) is expressed from human 293 cells (HEK293). It contains AA Met 26 - Arg 232 (Accession # G7Q0S7). In the region Met 26 - Arg 232, the AA sequence of Cynomolgus and Rhesus macaque IL-4 R alpha are homologus.
Molecule：IL-4 R alpha
Synonyms：IL4R,CD124,IL4RA
Species：Cynomolgus / Rhesus macaque
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Met 26 - Arg 232
Conjugate：Unconjugated
Molecular Weight：50.4 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
