86-7922-87　［取扱停止］Cynomolgus CD40 / TNFRSF5 Protein, His Tag 100ug　CD0-C52H6

特徴

• Background：CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
• CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation.
• The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
• CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines.
• The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily.
• Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules,which in turn interact with cytoplasmic components to initiate signaling pathways.
• Early studies on the CD40-CD40L system revealed its role in humoral immunity.
• Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.