86-7922-78　［取扱停止］Biotinylated Human VEGF121 Protein, Avitag,His Tag 25ug　VE1-H82E7

特徴

• Background：Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor (VPF) and VEGF-A, and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer.
• This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis.
• Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized.
• Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans.
• VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189.
• VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible.
• Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term, and show defects in skeletogenesis.
• Human VEGF121 shares 87% aa sequence identity with corresponding regions of mouse and rat, 93% with feline, equine and bovine, and 91%, 95% and 96% with ovine, canine and porcine VEGF, respectively.
• VEGF121 induces the proliferation of lymphatic endothelial cells.
• The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C.