86-7922-56 ［取扱停止］ActiveMax Human VEGF165 Protein, Tag Free (MALS verified) 50ug VE5-H4210
特徴
- Background：VEGF165 is the most abundant splice variant of VEGF-A.
- VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells.
- VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability.
- VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes.
- VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix.
- VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2.
- VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling.
- Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin.
- VEGF plays a key role in tumor angiogenesis in many cancers.
仕様
- サイズ：50ug
- Source：ActiveMax Human VEGF165, Tag Free (MALS verified) (VE5-H4210) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 191 (Accession # P15692-4).
- Molecule：VEGF165
- Synonyms：RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF
- Species：Human
- Tag：Tag Free
- Expression Systems：HEK293
- Expression Rigeion：Ala 27 - Arg 191
- Conjugate：Unconjugated
- Accession：NP_001165097.1
- Molecular Weight：19.2 kDa
- Characteristics：This protein carries no "tag". The protein has a calculated MW of 19.2 kDa. As a result of glycosylation, the protein migrates as 24 kDa (monomer) under reducing (R) condition, and 43-50 kDa (homodimer) under non-reducing (NR) condition (SDS-PAGE).
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>98% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：50ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7922-57
ActiveMax Human VEGF165 Protein, Tag Free (MALS verified) 20ug
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86-7922-56
ActiveMax Human VEGF165 Protein, Tag Free (MALS verified) 50ug
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