86-7922-52　［取扱停止］ActiveMax Human SCF / KITLG Protein, His Tag 20ug　SCF-H4219

特徴

• Background：Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117).
• SCF can exist both as a transmembrane protein and a soluble protein.
• This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.
• The soluble and transmembrane forms of the protein are formed by alternative splicing of the same RNA transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells.
• Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer.
• SCF plays an important role in the hematopoiesis during embryonic development.
• Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF.
• During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation.
• SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow.
• SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors.
• The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.