86-7922-36　［取扱停止］ActiveMax Human Erythropoietin / EPO Protein, Tag Free 50ug　EPO-H4214

特徴

• Background：Human Erythropoietin (EPO) is also known as EP, erythropoetin or erthropoyetin, and is a glycoprotein hormone that controls erythropoiesis, or red blood cell production.
• EPO is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow.
• is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver.
• Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation.
• Constitutively synthesized transcription factors for EPO, known as hypoxia-inducible factors (HIFs), are hydroxylated and proteosomally digested in the presence of oxygen.
• It binds to the erythropoietin receptor (EpoR) on the red cell surface and activates a JAK2 cascade.
• Erythropoietin has its primary effect on red blood cells by promoting red blood cell survival through protecting these cells from apoptosis.
• It also cooperates with various growth factors involved in the development of precursor red cells.
• EPO has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers.
• It has also been shown that erythropoietin can increase iron absorption by suppressing the hormone hepcidin.
• Erythropoietin has been shown to interact with the Erythropoietin receptor as its mechanism of action within the body.
• erythropoietin plays an important role in the brain's response to neuronal injury.
• EPO is also involved in the wound healing process.