Background：It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.
S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
仕様
サイズ：100ug
Source：SARS-CoV-2 Spike RBD (K417N, E484K, N501Y), Mouse IgG1 Fc Tag (SPD-C5254) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (K417N, E484K, N501Y)). K417N / E484K / N501Y mutations were identified in the SARS-CoV-2 Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2).
Molecule：Spike RBD
Synonyms：Spike,S protein RBD,Spike glycoprotein Receptor-binding domain,S glycoprotein RBD,Spike protein RBD
Species：SARS-CoV-2
Tag：Mouse IgG Fc Tag
Expression Systems：HEK293
Expression Rigeion：Arg 319 - Lys 537
Conjugate：Unconjugated
Accession：QHD43416.1 (K417N, E484K, N501Y)
Molecular Weight：50.9 kDa
Characteristics：This protein carries a mouse IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.9 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl,pH7.5
