Background：Nucleocapsid (N) protein is the most abundant protein found in coronavirus.
CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways.
It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M.
E., et al.
2017, Virology; 517: 62-68).
The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics.
Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.
仕様
サイズ：100ug
Source：MERS Nucleocapsid protein, His Tag (NUN-M52H5) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asp 413 (Accession # K0BVN3-1).
Molecule：Nucleocapsid protein
Synonyms：Nucleocapsid protein,NP,Protein N
Species：MERS
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Met 1 - Asp 413
Conjugate：Unconjugated
Molecular Weight：46.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. This protein contains a furin cleavage site, 251-RHKR-254, and is partially processed into N and C-terminal fragment with calculated MW of 17.1 kDa and 19.7 kDa respectively. The protein migrates as 23-25 kDa (C-terminus) and 46-73 kDa (full length) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
