Background：CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein.
CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain.
CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.
This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11.
The epsilon polypeptide plays an essential role in T-cell development.
CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency.
CD3E gene has also been linked to a susceptibility to type I diabetes in women.
CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
仕様
サイズ：100ug
Source：Human CD3 epsilon, His Tag (CDE-H5223) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # P07766-1).
Molecule：CD3 epsilon
Synonyms：FLJ18683,T3E,TCRE,CD3E,CD3-epsilon
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Asp 23 - Asp 126
Conjugate：Unconjugated
Accession：NP_000724.1
Molecular Weight：16.9 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.9 kDa. As a result of glycosylation, the protein migrates as 20-21 kDa under reducing (R) condition, and 35-45 kDa under non-reducing (NR) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
