Background：CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein.
CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain.
CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.
This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11.
The epsilon polypeptide plays an essential role in T-cell development.
CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency.
CD3E gene has also been linked to a susceptibility to type I diabetes in women.
CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
仕様
サイズ：100ug
Source：Human CD3 epsilon, Mouse IgG2a Fc Tag (CDN-H5253) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # NP_000724.1).
Molecule：CD3 epsilon
Synonyms：FLJ18683,T3E,TCRE,CD3E,CD3-epsilon
Species：Human
Tag：Mouse IgG Fc Tag
Expression Systems：HEK293
Expression Rigeion：Asp 23 - Asp 126
Conjugate：Unconjugated
Accession：NP_000724.1
Molecular Weight：38.6 kDa
Characteristics：This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 38.6 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
