Background：Nucleocapsid (N) protein is the most abundant protein found in coronavirus.
CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways.
It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M.
E., et al.
2017, Virology; 517: 62-68).
The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics.
Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.
仕様
サイズ：100ug
Source：SARS-CoV-2 Nucleocapsid protein, His Tag (NUN-C52H8) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1). D3L/ R203K/ G204R/ S235F were identified in the SARS-CoV-2 Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01) (data retrieved from https://pubmed.ncbi.nlm.nih.gov/33095454/).
Molecule：Nucleocapsid protein
Synonyms：Nucleocapsid protein,NP,Protein N
Species：SARS-CoV-2
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Met 1 - Ala 419
Conjugate：Unconjugated
Accession：QHO62115.1
Molecular Weight：47.4 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.4 kDa. The protein migrates as 30-35 kDa and 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
