86-7919-16　［取扱停止］ActiveMax Human IL-7 Protein, Tag Free, Ultra-low endotoxin (MALS verified) 50ug　IL7-H4219

特徴

• Background：Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus.
• It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes.
• IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells).
• It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis.
• IL-7 is a cytokine important for B and T cell development.
• This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
• IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor.
• Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma).
• Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients.
• IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection.
• IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.