Background：Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
TNFRSF-8 is expressed by activated, but not by resting, T and B cells.
Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15.
CD30 is the receptor for TNFSF8/CD30L.
CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B.
TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts.
TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
仕様
サイズ：25ug
Source：Biotinylated Human CD30, Fc,Avitag (CD0-H82F4) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2).
Molecule：CD30
Synonyms：TNFRSF8,CD30,D1S166E,Ki-1
Species：Human
Tag：Fc Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Phe 19 - Lys 379
Conjugate：Precision Avi
Accession：NP_001234.2
Molecular Weight：66.6 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 66.6 kDa. The protein migrates as 80-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
