Background：Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins.
Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life.
Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis.
Its expression is not detected in the corresponding normal tissues.
仕様
サイズ：25ug
Source：Biotinylated Human Nectin-4 (244-349), His,Avitag (NE4-H82Ed) is expressed from human 293 cells (HEK293). It contains AA Phe 244 - Ser 349 (Accession # Q96NY8-1).
Molecule：Nectin-4
Synonyms：NECTIN4,LNIR, PRR4, PVRL4
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Phe 244 - Ser 349
Conjugate：Precision Avi
Accession：NP_112178.2
Molecular Weight：15.2 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 15.2 kDa. The protein migrates as 18 kDa and 19-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
