Background：G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.
Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis.
Plays an important role in mediating the responses to fasting.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Promotes activation of adenylate cyclase.
Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
仕様
サイズ：50ug
Source：Mouse GCGR, Fc Tag (GCR-M5254) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Lys 137 (Accession # Q61606-1).
Molecule：GCGR
Synonyms：Glucagon R, GCGR,Glucagon receptor
Species：Mouse
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ala 27 - Lys 137
Conjugate：Unconjugated
Accession：NP_032127.2
Molecular Weight：39.5 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
