Background：Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells.
CLDN18 is specifically expressed in the stomach and lung.
Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific.
CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
仕様
サイズ：20ug
Source：Human Claudin-18.2, His Tag (CL2-H5546) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2).
Molecule：Claudin-18.2
Synonyms：Claudin-18.2,CLDN18,Claudin-18
Species：Human
Tag：His Tag
Expression Systems：InsectCells
Expression Rigeion：Met 1 - Ala 200
Conjugate：Unconjugated
Accession：NP_001002026.1
Molecular Weight：23.0 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 23.0 kDa.
It is produced as active membrane protein with full ECD epitopes, and contains both the ECL1 and ECL2.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
