Background：Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135.
FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III.
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.
Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.
Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1.
Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
仕様
サイズ：25ug
Source：Biotinylated Human Flt-3, His,Avitag (FL3-H82E3) is expressed from human 293 cells (HEK293). It contains AA Asn 27 - Ser 543 (Accession # P36888-1).
Molecule：Flt-3
Synonyms：Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Asn 27 - Ser 543
Conjugate：Precision Avi
Accession：NP_004110.2
Molecular Weight：62.1 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 62.1 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
