Background：PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes.
Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle.
Also expressed in erythroleukemia cells.
Inactive tyrosine kinase involved in Wnt signaling pathway.
Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway.
Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis.
Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
仕様
サイズ：100ug
Source：Cynomolgus / Rhesus macaque PTK7, His Tag (PT7-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 39 - Thr 712 (Accession # A0A2K5VNI5-1). In the region Ala 39 - Thr 712, the AA sequence of Cynomolgus and Rhesus macaque PTK7 are homologus.
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.5 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
