Background：Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6.
CD47 is very broadly distributed on normal adult tissues.
CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity.
CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
仕様
サイズ：25ug
Source：Biotinylated Human CD47, Mouse IgG2a Fc,Avitag (CD7-H82A3) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139 (Accession # Q08722-3).
Molecule：CD47
Synonyms：CD47,MER6,IAP,OA3
Species：Human
Tag：Mouse IgG Fc Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gln 19 - Pro 139
Conjugate：Precision Avi
Accession：NP_942088.1
Molecular Weight：42.3 kDa
Characteristics：This protein carries a mouse IgG2a Fc tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 42.3 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
