Background：Semaphorin-3A (SEMA3A) is also known as Semaphorin III, which belongs to the semaphorin family.
SEMA3A contains 1 Ig-like C2-type (immunoglobulin-like) domain, one PSI domain amd one sema domain.
Semaphorin-3A is a secreted proteins, or chemorepulser, secreted by surrounding tissues to guide migrating cells and axons in the developing nervous system of an organism which is critical for the precise formation of neurons and vasculature.
SEMA3A can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites.
In both cases, the protein is vital for normal neuronal pattern development.
Increased expression of SEMA3A is associated with schizophrenia and is seen in a variety of human tumor cell lines.
Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
仕様
サイズ：100ug
Source：Human Semaphorin 3A, Fc Tag (SEA-H5257) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Val 771 (Accession # Q14563-1 (R552A, R555A)).
Characteristics：This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 112.4 kDa. Besides Furin cleavage site (Arg 555 - Gln 556), the protein also has an unknown protease cleavage site at Leu 709 - Ile 710. The protein migrates as 100 kDa and 116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
