Background：FAP (also known as seprase) is a Type II transmembrane serine protease.
Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asla consensus sequences.
Degrade also gelatin, heat-denatured type I collagen.
Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro.
The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM.
Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican.
Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
仕様
サイズ：100ug
Source：Cynomolgus FAP, His Tag (FAP-C52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 760 (Accession # XP_005573377.1).
Molecule：FAP
Synonyms：FAP,FAPalpha,SIMP,Seprase,APCE
Species：Cynomolgus
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Leu 26 - Asp 760
Conjugate：Unconjugated
Accession：XP_005573377.1
Molecular Weight：90.8 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 90.8 kDa. The protein migrates as 85-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
