Background：NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1.
NKG2D itself forms a homodimer whose ectodomains serve for ligand binding.
NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer.
In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity.
The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.
仕様
サイズ：25ug
Source：FITC-Labeled Human NKG2D, Fc Tag (NKD-HF224) is expressed from human 293 cells (HEK293). It contains AA Ile 73 - Val 216 (Accession # P26718-1). It is the biotinylated form of Human NKG2D, Fc Tag (HPLC-verified) (Cat. No.NKD-H5265).
Molecule：NKG2D
Synonyms：NKG2D,CD314,KLRK1,NK cell receptor D
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ile 73 - Val 216
Conjugate：FITC Labeled Protein
Accession：NP_031386.2 (T72A)
Molecular Weight：43.1 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 43.1 kDa. The protein migrates as 75-110 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
