Background：Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells.
Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells.
CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation.
CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses.
CD70 induces proliferation and IFNγ production, on NK cells.
仕様
サイズ：25ug
Source：FITC-Labeled Human CD27 Ligand, His,Flag Tag (CDD-HF2D4) is expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193 (Accession # P32970-1). It is the biotinylated form of Human CD27 Ligand, His,Flag Tag (active trimer) (MALS verified) (Cat. No.CDL-H52Da).
Molecule：CD27 Ligand
Synonyms：CD70,CD27LG,TNFSF7,TNFSF7G,CD27L
Species：Human
Tag：His Tag & Flag Tag
Expression Systems：HEK293
Expression Rigeion：Ser 52 - Pro 193
Conjugate：FITC Labeled Protein
Accession：NP_001243.1
Molecular Weight：49.3 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag. The protein has a calculated MW of 49.3 kDa. The protein migrates as 50-55 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
