Background：Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins.
NKG2C plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
The CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E is coupled to the KARAP/DAP12 adapter in a subset of NK cells, triggering their effector functions.
CD94/NKG2C may operate as an alternative activation pathway for a subset of CD8+ T lymphocytes, triggering their effector functions and proliferation upon specific ligand engagement.
仕様
サイズ：100ug
Source：Human NKG2C, His Tag (NKC-H5248) is expressed from human 293 cells (HEK293). It contains AA Ile 94 - Leu 231 (Accession # P26717-1).
Molecule：NKG2C
Synonyms：NKG2C,NKG2-C,CD159c,KLRC2,NK cell receptor C
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ile 94 - Leu 231
Conjugate：Unconjugated
Molecular Weight：17.8 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.8 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
