Background：ILDR2 belongs to the immunoglobulin superfamily.
May be involved in lipid homeostasis and ER stress pathways.
ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues.
A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells.
Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.
仕様
サイズ：100ug
Source：Human ILDR2, Fc Tag (IL2-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Glu 186 (Accession # Q71H61-1).
Molecule：ILDR2
Synonyms：ILDR2,C1orf32
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Leu 21 - Glu 186
Conjugate：Unconjugated
Accession：NP_955383.1
Molecular Weight：45.1 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
