Background：The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure.
We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs.
Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.
The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
仕様
サイズ：100ug
Source：Cynomolgus Siglec-10, His Tag (SI0-C52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - Ala 549 (Accession # A0A2K5WBX8-1).
Molecule：Siglec-10
Synonyms：SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Species：Cynomolgus
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Thr 17 - Ala 549
Conjugate：Unconjugated
Molecular Weight：60.2 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：25 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.0
