Background：APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA.
APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies.
The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes.
Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share.
BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities.
In addition, expression of APRIL was regulated by miR-145 in GC cells.
仕様
サイズ：100ug
Source：Human APRIL, His,Flag Tag, active trimer (APL-H52D1) is expressed from human 293 cells (HEK293). It contains AA Gln 111 - Leu 250 (Accession # O75888-1) trimer Design.
Characteristics：This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag. The protein has a calculated MW of 50.2 kDa. The protein migrates as 50-55 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
