Background：Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily.
FOLH1 / PSMA is stable at pH greater than 6.5.
FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine.
FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity.
The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly – gamma - glutamates.
FOLH1 / GCP-2 / PSMA has both folate hydrolase and N – acetylated – alpha – linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides.
GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity.
In vitro, cleaves Gly-Pro-AMC.
仕様
サイズ：25tests
Source：PE-Labeled Human PSMA, His Tag (PSA-HP2Q3) is produced via site-specific conjugation of PE to Human PSMA, His Tag under optimal conditions with a proprietary technology with a proprietary technology. Human PSMA, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 44 - Ala 750 (Accession # Q04609-1).
