Background：GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP.
Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury.
GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C.
Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
仕様
サイズ：100ug
Source：Mouse GUCY2C, His Tag (GUC-M52H3) is expressed from human 293 cells (HEK293). It contains AA Val 20 - Met 433 (Accession # Q3UWA6-1).
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-100 kD under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
