86-7915-97 ［取扱停止］Human FAP Protein, His Tag (MALS verified) (active enzyme) 20ug FAP-H5244
特徴
- Background：FAP (also known as seprase) is a Type II transmembrane serine protease.
- Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asla consensus sequences.
- Degrade also gelatin, heat-denatured type I collagen.
- Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro.
- The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM.
- Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican.
- Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
仕様
- サイズ：20ug
- Source：Human FAP, His Tag (MALS verified) (FAP-H5244) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 760 (Accession # Q12884-1).
- Molecule：FAP
- Synonyms：FAP,FAPalpha,SIMP,Seprase,APCE
- Species：Human
- Tag：His Tag
- Expression Systems：HEK293
- Expression Rigeion：Leu 26 - Asp 760
- Conjugate：Unconjugated
- Accession：NP_004451.2
- Molecular Weight：86.9 kDa
- Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 86.9 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：20ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7915-98
Human FAP Protein, His Tag (MALS verified) (active enzyme) 100ug
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86-7915-97
Human FAP Protein, His Tag (MALS verified) (active enzyme) 20ug
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